"Aishite Knight" is set in Osaka, and tells the story of Yaeko "Yakko" Mitamura, an 18-year-old girl working in her father's Okonomiyaki restaurant. One day Yakko casually meets a little boy, Hashizo, and his odd cat Juliano. Hashizo has lost both parents when still a baby and has been brought up by his elder brother. Hashizo's brother Go Kato is the lead singer of the emerging rock band "Bee Hive". When Yakko meets Go and his friend and "Bee Hive" member Satomi Okawa an unexpected series of events unfolds.