Like the earlier Battle Royales, a class of middle school students are picked to compete in fights to the death on an island until there is only one left.

The manga follows the point of view of Girl #10 Makoto Hashimoto, an unlucky girl who fears that her class will be chosen to participate in "the program," a mysterious event that forces students to kill each other. Makoto attends Shikanotoride Junior High School. After the encouragement of her best friend Itou Yamamoto and her mother she decides to face the chances. Her fears are supposedly put to rest when word spreads that all 50 Programs had already been executed in the year making them 100% unlikely to participate....